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The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
Time-lapse video of mitosis in a Drosophila melanogaster embryo. The primary result of mitosis and cytokinesis is the transfer of a parent cell's genome into two daughter cells. The genome is composed of a number of chromosomes—complexes of tightly coiled DNA that contain genetic information vital for proper cell function. [32]
[5] [6] After growth from the zygote to the adult, cell division by mitosis allows for continual construction and repair of the organism. [7] The human body experiences about 10 quadrillion cell divisions in a lifetime. [8] The primary concern of cell division is the maintenance of the original cell's genome.
Schematic karyogram of the human chromosomes, showing their usual state in the G 0 and G 1 phase of the cell cycle. At top center it also shows the chromosome 3 pair in metaphase (annotated as "Meta."), which takes place after having undergone DNA synthesis which occurs in the S phase (annotated as S) of the cell cycle.
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In order for asymmetric division to take place the mother cell must be polarized, and the mitotic spindle must be aligned with the axis of polarity. The cell biology of these events has been most studied in three animal models: the mouse, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster.