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  2. Insulin-like growth factor 1 - Wikipedia

    en.wikipedia.org/wiki/Insulin-like_growth_factor_1

    Low IGF-1 levels are associated with cardiovascular disease, while high IGF-1 levels are associated with cancer. Mid-range IGF-1 levels are associated with the lowest mortality. A synthetic analog of IGF-1, mecasermin, is used for the treatment of growth failure in children with severe IGF-1 deficiency. [15]

  3. Insulin-like growth factor - Wikipedia

    en.wikipedia.org/wiki/Insulin-like_growth_factor

    IGF-1 has an involvement in regulating neural development including neurogenesis, myelination, synaptogenesis, and dendritic branching and neuroprotection after neuronal damage. Increased serum levels of IGF-I in children have been associated with higher IQ. [5] IGF-1 shapes the development of the cochlea through controlling apoptosis.

  4. Laron syndrome - Wikipedia

    en.wikipedia.org/wiki/Laron_syndrome

    LS should be suspected in children or adults with distinctive physical features listed above, extremely elevated serum hGH concentrations despite low serum IGF-1 levels. [14] A failure of IGF-1 to increase in response to exogenous hGH (IGF-1 stimulation test) is diagnostic for LS. [14]

  5. Imagine living in a 4-foot body that doesn’t develop chronic ...

    www.aol.com/news/meet-little-people-whose-bodies...

    And because low levels of IGF-1 in those without the mutation have been linked in studies with a higher risk of cardiovascular disease, “everybody assumed that people with Laron probably had a ...

  6. Growth hormone deficiency - Wikipedia

    en.wikipedia.org/wiki/Growth_hormone_deficiency

    [9] [15] It may be appropriate in diagnosed adult-onset deficiency, where a weekly dose of approximately 25% of that given to children is given. Lower doses again are called for in the elderly to reduce the incidence of side effects and maintain age-dependent normal levels of IGF-1. [24]

  7. Growth hormone - Wikipedia

    en.wikipedia.org/wiki/Growth_hormone

    IGF-1 has growth-stimulating effects on a wide variety of tissues. Additional IGF-1 is generated within target tissues, making it what appears to be both an endocrine and an autocrine/paracrine hormone. IGF-1 also has stimulatory effects on osteoblast and chondrocyte activity to promote bone growth. In addition to increasing height in children ...

  8. Mecasermin - Wikipedia

    en.wikipedia.org/wiki/Mecasermin

    Mecasermin, sold under the brand name Increlex, also known as recombinant human insulin-like growth factor-1 (rhIGF-1), is a recombinant form of human insulin-like growth factor 1 (IGF-I) which is used in the long-term treatment of growth failure and short stature in children with severe primary IGF-I deficiency, for instance due to growth hormone deficiency or Laron syndrome (growth hormone ...

  9. Isolated growth hormone deficiency - Wikipedia

    en.wikipedia.org/wiki/Isolated_growth_hormone...

    The diagnosis of growth hormone deficiency is a multi-step procedure that involves pituitary MRI, biochemical testing (growth hormone stimulation tests and measurement of IGF-1/IGFBP3), clinical and auxological examination, and genetic test results. [8]

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