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Figure 1. Probabilistic parameters of a hidden Markov model (example) X — states y — possible observations a — state transition probabilities b — output probabilities. In its discrete form, a hidden Markov process can be visualized as a generalization of the urn problem with replacement (where each item from the urn is returned to the original urn before the next step). [7]
A profile HMM modelling a multiple sequence alignment. HMMER is a free and commonly used software package for sequence analysis written by Sean Eddy. [2] Its general usage is to identify homologous protein or nucleotide sequences, and to perform sequence alignments.
A hidden Markov model is a Markov chain for which the state is only partially observable or noisily observable. In other words, observations are related to the state of the system, but they are typically insufficient to precisely determine the state. Several well-known algorithms for hidden Markov models exist.
The following picture presents a Bayesian network of a HMM. Hidden Markov model. Because of the Markov assumption, the probability of the current true state given the immediately previous one is conditionally independent of the other earlier states.
The hierarchical hidden Markov model (HHMM) is a statistical model derived from the hidden Markov model (HMM). In an HHMM, each state is considered to be a self-contained probabilistic model. More precisely, each state of the HHMM is itself an HHMM. HHMMs and HMMs are useful in many fields, including pattern recognition. [1] [2]
The forward–backward algorithm is an inference algorithm for hidden Markov models which computes the posterior marginals of all hidden state variables given a sequence of observations/emissions ::=, …,, i.e. it computes, for all hidden state variables {, …,}, the distribution ( | :).
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A profile hidden Markov model (HMM) modelling a multiple sequence alignment. A hidden Markov model (HMM) is a probabilistic model that can assign likelihoods to all possible combinations of gaps, matches, and mismatches, to determine the most likely MSA or set of possible MSAs. HMMs can produce a single highest-scoring output but can also ...