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This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
Anti-cancer monoclonal antibodies can be targeted against malignant cells by several mechanisms. Ramucirumab is a recombinant human monoclonal antibody and is used in the treatment of advanced malignancies. [18] In childhood lymphoma, phase I and II studies have found a positive effect of using antibody therapy. [19]
Denosumab, sold under the brand names Prolia among others, is a human monoclonal antibody used for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. [11] [12] The most common side effects are joint and muscle pain in the arms or legs. [13]
WPBF's Ana Espinosa on the local shortage of monoclonal antibody treatments, and updates on when distribution sites expect to restock. Local monoclonal antibody treatment shortage [Video] Skip to ...
Dr. Narayanan says that bone pain can also be a sign of prostate cancer recurrence in patients who have already had the disease. The link between prostate cancer and bone pain may be a surprising one.
Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide , a derivative of DTPA . [ 2 ] Pendetide acts as a chelating agent for the radionuclide indium-111 .
Clinical trials for Carlumab include studies of idiopathic pulmonary fibrosis, [8] [9] castration-resistant metastatic prostate cancer [1] [10] and solid tumors. [ 11 ] [ 12 ] Carlumab was being developed by Janssen Biotech prior to discontinuation in 2012 [ 13 ] due to limited success in clinical trials.
Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. [18] It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in children and adults, but not recommended in elderly patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura ...