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The increase in breast cancer risk with estrogen and progestogen therapy was shown to be causal with conjugated estrogens plus medroxyprogesterone acetate in the Women's Health Initiative randomized controlled trials. [122] [155] Breast cancer risk with combined estrogen and progestogen therapy may differ depending on the progestogen used.
In the largest (1996) reanalysis of previous studies of hormonal contraceptives and breast cancer risk, less than 1% were POP users. Current or recent POP users had a slightly increased relative risk (RR 1.17) of breast cancer diagnosis that just missed being statistically significant.
Norethisterone stimulates the proliferation of MCF-7 breast cancer cells in vitro, an action that is independent of the classical PRs and is instead mediated via the progesterone receptor membrane component-1 (PGRMC1). [70] Certain other progestins act similarly in this assay, whereas progesterone acts neutrally. [70]
Researchers from the Danish Cancer Society Research Center have found an association between levonorgestrel-releasing intrauterine systems (LNG-IUSs) and increased breast cancer risk in females ...
Initially, I was wary about using an estrogen product because my breast cancer was hormone sensitive, but he reaffirmed that the research regarding topical estrogen and breast cancer risk shows ...
Higher breast density is a strong known risk factor for breast cancer. [125] Other studies have had mixed findings however. [126] A 2018 systematic review reported that breast density with an estrogen plus oral progesterone was significantly increased in three studies and unchanged in two studies. [126]
Cervical cancer risk in those infected with HPV is increased. [124] A similar small increase in breast cancer risk was observed in other meta analyses. [125] [126] A study of 1.8 million Danish women of reproductive age followed for 11 years found that the risk of breast cancer was 20% higher among those who currently or recently used hormonal ...
Norethisterone acetate (NETA), also known as norethindrone acetate and sold under the brand name Primolut-Nor among others, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders.
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