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Vitamin A supplementation of children under five who are at risk of VAD has been found to reduce all‐cause mortality by 12 to 24%. [30] Side effects of vitamin A supplements are rare. Vitamin A toxicity is a rare concern associated with high levels of vitamin A over prolonged periods of time.
Xerophthalmia (from Ancient Greek xērós (ξηρός) meaning "dry" and ophthalmos (οφθαλμός) meaning "eye") is a medical condition in which the eye fails to produce tears. It may be caused by vitamin A deficiency, [1] which is sometimes used to describe that condition, although there may be other causes.
Vitamin A status involves eye health via two separate functions. Retinal is an essential factor in rod cells and cone cells in the retina responding to light exposure by sending nerve signals to the brain. An early sign of vitamin A deficiency is night blindness. [6] Vitamin A in the form of retinoic acid is essential to normal epithelial cell ...
A major cause of Bitot's spots is vitamin A deficiency (VAD). [4] Rarely, pellagra due to deficiency of vitamin B 3 (niacin) may also cause Bitot's spots. [5] They can also be caused by Colestyramine , which is a bile acid sequestrant which can reduce the absorption of fat soluble vitamins (Vitamins A, D, E, K)
Stopping high vitamin A intake is the standard treatment. Most people fully recover. Phosphatidylcholine (in the form of PPC or DLPC), the substrate for lecithin retinol acyltransferase, which converts retinol into retinyl esters (the storage forms of vitamin A). Vitamin E may alleviate hypervitaminosis A. [34]
Keratomalacia is an eye disorder that results from vitamin A deficiency. Vitamin A is required to maintain specialized epithelia (such as in the cornea and conjunctiva ). The precise mechanism is still not known, but vitamin A is necessary for the maintenance of the specialized epithelial surfaces of the body.
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An ocular manifestation of a systemic disease is an eye condition that directly or indirectly results from a disease process in another part of the body. There are many diseases known to cause ocular or visual changes.
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