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Download as PDF; Printable version; ... Drugs and other substances that have been associated with significant hepatotoxicity (liver damage). ...
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver. It can be a side-effect , but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids , or in laboratory environments, such as carbon tetrachloride , or far more pervasively in the form of ethanol (drinking alcohol).
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.
Download as PDF; Printable version ... This is opposite to hepatotoxicity. ... Acetylcysteine is considered the hepatoprotective drug of choice when treating an ...
Data from Drug Induced Liver Injury Network reported the rates of liver injury due to botanical products has been on the rise from 7% in 2004-2005 to 20% in 2013-2014.
Myelosuppression, peripheral neuropathy, seizures and hepatotoxicity (rare). Bleomycin: IM, SC, IA, IV or IP: Inhibits DNA and to a lesser extent RNA synthesis, produces single and double strand breaks in DNA possibly by free radical formation.
Furthermore, the researchers estimated that 15.6 million U.S. adults have taken at least one herbal supplement in the last 30 days that might be hepatotoxic or damaging to their liver.
For example, antibiotics that kill gut bacteria often reduce enterohepatic drug circulation and this requires a temporary increase of the drug's dose until the antibiotic use is discontinued and the gut repopulates with bacteria. This effect of antibiotics on enterohepatic circulation of other drugs is one of several types of drug interactions.