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ISGs are genes whose expression can be stimulated by interferon, but may also be stimulated by other pathways. [1] Interferons are a type of protein called a cytokine, which is produced in response to infection. [9] When released, they signal to infected cells and other nearby cells that a pathogen is present. [9]
Interferome is an online bioinformatics database of interferon-regulated genes (IRGs). [1] These Interferon Regulated Genes are also known as Interferon Stimulated Genes (ISGs). The database contains information on type I (IFN alpha, beta), type II (IFN gamma) and type III (IFN lambda) regulated genes and is regularly updated.
9636 100038882 Ensembl ENSG00000187608 ENSMUSG00000035692 UniProt P05161 Q64339 RefSeq (mRNA) NM_005101 NM_015783 RefSeq (protein) NP_005092 NP_056598 Location (UCSC) Chr 1: 1 – 1.01 Mb Chr 4: 156.28 – 156.29 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. ISG15 is ...
15959 Ensembl ENSG00000119917 ENSMUSG00000074896 UniProt O14879 Q64345 RefSeq (mRNA) NM_001549 NM_001031683 NM_001289758 NM_001289759 NM_010501 RefSeq (protein) NP_001026853 NP_001276687 NP_001276688 NP_001540 NP_034631 Location (UCSC) Chr 10: 89.33 – 89.38 Mb Chr 19: 34.56 – 34.57 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon-induced protein with tetratricopeptide ...
Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. [ 5 ] STING plays an important role in innate immunity .
STAT1 homodimers are involved in type II interferon signalling, and bind to the GAS (Interferon-Gamma Activated Sequence) promoter to induce expression of interferon stimulated genes (ISG). In type I interferon signaling, STAT1-STAT2 heterodimer combines with IRF9 (Interferon Response Factor) to form ISGF3 (Interferon Stimulated Gene Factor ...
It took another fifteen to twenty years, using somatic cell genetics, to show that the interferon action gene and interferon gene reside in different human chromosomes. [71] [72] [73] The purification of human beta interferon did not occur until 1977. Y.H. Tan and his co-workers purified and produced biologically active, radio-labeled human ...
Interferon-induced protein with tetratricopeptide repeats 2 (commonly termed IFIT2) is a protein that in humans is directed to be produced by the IFIT2 gene. [5] [6] [7] Previously, this gene was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 gene and the protein that it directs to be produced was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54 ...