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The GFR, however, does not reveal the source of the kidney disease. This is accomplished by urinalysis, measurement of urine protein excretion, kidney imaging, and, if necessary, kidney biopsy. [1] Much of renal physiology is studied at the level of the nephron – the smallest functional unit of the kidney
Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3] Affected female dogs have protein in the urine and a failure to gain a normal amount of weight, but are usually otherwise normal.
Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. [4] Central to the physiologic maintenance of GFR is the differential basal tone of the afferent (input) and efferent (output) arterioles (see diagram).
The kidney is divided into parenchyma and renal sinus. The renal sinus is hyperechoic and is composed of calyces, the renal pelvis, fat and the major intrarenal vessels. In the normal kidney, the urinary collecting system in the renal sinus is not visible, but it creates a heteroechoic appearance with the interposed fat and vessels.
Madin-Darby canine kidney (MDCK) cells are a model mammalian cell line used in biomedical research. MDCK cells are used for a wide variety of cell biology studies including cell polarity , cell-cell adhesions (termed adherens junctions ), collective cell motility, toxicity studies, [ 1 ] as well as responses to growth factors.
With normal kidney (renal) function, glucose is excreted in the urine only when there are abnormally elevated levels of glucose in the blood. However, in those with renal glycosuria , glucose is abnormally elevated in the urine due to improper functioning of the renal tubules, which are primary components of nephrons , the filtering units of ...
Dogs have ear mobility that allows them to rapidly pinpoint the exact location of a sound. Eighteen or more muscles can tilt, rotate, raise, or lower a dog's ear. A dog can identify a sound's location much faster than a human can, as well as hear sounds at four times the distance. [41] Dogs can lose their hearing from age or an ear infection. [42]
Renal hypoplasia is a congenital abnormality in which one or both of the kidneys are smaller than normal, [5] resulting in a reduced nephron number [1] but with normal morphology. [ 4 ] It is defined as abnormally small kidneys, where the size is less than two standard deviations below the expected mean for the corresponding demographics , and ...
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