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Peptide therapeutics are peptides or polypeptides used to treat diseases. They can mimic natural hormones, growth factors, neurotransmitters, and anti-infectives. Learn how they work, how they are modified, and how they are delivered.
Antimicrobial peptides (AMPs) are part of the innate immune response found among all classes of life. They are potent, broad spectrum antimicrobials that kill bacteria, fungi, viruses and cancer cells by various mechanisms.
RMAT stands for regenerative medicine advanced therapy, a designation by the FDA for drug candidates that treat serious or life-threatening conditions. RMAT allows for accelerated approval based on surrogate endpoints and early interactions with the FDA.
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content modulation through splicing site binding on pre-mRNA. [1]
Plant cell culture was used to produce FDA-approved glycosylated lysosomal protein-drug, and additional drug candidates. [11] Recent studies have shown that it may be possible to produce recombinant lysosomal proteins with microorganisms such as Escherichia coli and Saccharomyces cerevisiae . [ 12 ]
Not to be confused with Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors. Hypoxia-inducible factor prolyl hydroxylase Inhibitors (HIF-PHIs) also known as hypoxia-inducible factor stabilizers (HIF stabilizers) are a novel class of drugs that act by inhibiting hypoxia-inducible factor-proline dioxygenase (HIF prolyl-hydroxylase) which is responsible for breaking down the hypoxia ...
Some DPP-4 inhibitor drugs have received approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production.
Protein therapeutics are proteins used as experimental or approved therapies for disease states. They include "monoclonal antibodies (mAbs), peptide hormones, growth factors, plasma proteins, enzymes, and hemolytic factors" [1] While proteins can be more specific and flexible in their mechanism of action compared to small-molecule drugs, duration of action and drug delivery can be a challenge.