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Durvalumab, [8] sold under the brand name Imfinzi, is an anti-cancer medication used for treatment of various types of cancer. [6] It was developed by Medimmune / AstraZeneca . [ 9 ] It is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody that blocks the interaction of programmed cell death ligand 1 ( PD-L1 ).
Durvalumab is FDA approved for the treatment of urothelial carcinoma and unresectable non-small cell lung cancer after chemoradiation. [ 33 ] Cosibelimab (Unloxcyt) by Checkpoint Therapeutics is a PD-L1 inhibitor developed by Dana Farber, and was approved in the United States in December 2024 for cutaneous squamous cell carcinoma .
Cancer immunotherapy (immuno-oncotherapy) is the stimulation of the immune system to treat cancer, improving the immune system's natural ability to fight the disease. [1] It is an application of the fundamental research of cancer immunology (immuno-oncology) and a growing subspecialty of oncology.
The sporting dog should have access to water at all times. This is due to the fact that water intake needs are constantly adapting based on body water stores, exercise, food type, and sodium intake.12,13 Sporting dogs fed a raw or wet diet receive additional water from the high moisture content of these food types.
During growth, young dogs are more susceptible to infection, but the addition of proper levels of vitamin E to the diet reduces free radical oxidative damage and leads to an increase in immunity. Calcium and phosphorus, in the appropriate amounts and ratio, aid in proper bone and cartilage growth and maturation.
Tremelimumab is indicated, in combination with durvalumab, for the treatment of adults with unresectable hepatocellular carcinoma. [7] [11] [8]Tremelimumab in combination with durvalumab and platinum-based chemotherapy is indicated for the first-line treatment of adults with metastatic non-small cell lung cancer with no sensitizing epidermal growth factor receptor mutations or anaplastic ...
Although daily brushing provides the best preventative measure, feeding a dental diet or using dental chews for dogs is an effective approach pet owners can take to help prevent and control accumulation of plaque and tartar to avoid consequences of severe periodontal disease. [2]
The senior dog population consists of dogs that are over the age of seven for most dog breeds, [1] though in general large and giant breed dogs tend to reach this life stage earlier when compared to smaller breed dogs. Senior dog foods contain nutrients and characteristics that are used to improve the health of the aging dog.
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