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Stiff-person syndrome (SPS), also known as stiff-man syndrome, [1] is a rare neurological disorder of unclear cause characterized by progressive muscular rigidity and stiffness. The stiffness primarily affects the truncal muscles and is characterised by spasms , resulting in postural deformities.
Celine Dion took to the stage for the first time since revealing her stiff-person syndrome diagnosis in September 2022. Wearing a white gown, with the rain beating down and the Eiffel Tower in the ...
Céline Dion is speaking out about stiff person syndrome (SPS), a diagnosis she first revealed nearly two years ago. SPS is a rare autoimmune neurological disease that affects muscles and ...
Many patients with stiff person syndrome experience muscle cramping, spasms and stiffness constantly, but certain movements or emotions can trigger "a complete, whole-body spasm," Piquet, who is a ...
Stiff person syndrome, which occurs in about one in 1 million people, is characterized by progressive muscle rigidity which leads to impaired mobility, muscle spasms, postural deformities and ...
Hyoscine butylbromide, also known as scopolamine butylbromide [4] and sold under the brandname Buscopan among others, [5] is an anticholinergic medication used to treat abdominal pain, esophageal spasms, bladder spasms, biliary colic, [6] and renal colic. [7] [8] It is also used to improve excessive respiratory secretions at the end of life. [9]
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High titers of autoantibodies to glutamic acid decarboxylase (GAD) are well documented in association with stiff person syndrome (SPS). [35] Glutamic acid decarboxylase is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA), and impaired function of GABAergic neurons has been implicated in the pathogenesis of SPS.
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