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Infantile digital fibroma lesions were once thought to be potentially malignant and therefore treated with surgical excision and even digital amputations. [8] Currently, these tumors are known to be benign, [4] may spontaneously regress, and often recur after surgical removal. [8]
However, mesoblastic nephroma tumor cells, unlike IMF tumor cells, express cyclin D1 and Beta-catenin proteins and therefore likely have a very different cellular origin than IMF tumors. [ 22 ] [ 23 ] Infantile digital fibromatosis , a tumor that develops primarily in the fingers and toes, had been regarded as a type of IMF.
Infantile myofibromatosis: solitary tumors commonly occurring in the head and neck regions; multiple tumors occurring in the skin, subcutaneous tissue, muscles, and/or less commonly bones; or, rarely, tumors occurring in an internal organ(s). [4] Aponeurotic fibroma; Infantile digital fibromatosis; Aggressive infantile fibromatosis
Histopathologically, FMTs consist of neoplastic connective tissue cells which have differented into cells that have microscopic appearances resembling fibroblasts and/or myofibroblasts. The fibroblastic cells are characterized as spindle-shaped cells with inconspicuous nucleoli that express vimentin , an intracellular protein typically found in ...
A dermatofibroma, or benign fibrous histiocytomas, is a benign nodule in the skin, typically on the legs, elbows or chest of an adult. [3] It is usually painless. [3] It usually ranges from 0.2cm to 2cm in size but larger examples have been reported. [3] It typically results from mild trauma such as an insect bite. [3]
The largest study to date examined 197 cases of FHI. In this study, most individuals presented with a slowly growing, symptomless, subcutaneous mass although rarely these masses were rapidly growing, and/or were tender, painful, warm, and/or were accompanied by skin changes, pigmentation, sweat gland enlargement, and/or increased hair overlaying the tumor.
Similarities among bland spindle-cell lesions lead to a large number of possibilities in diagnosis, including fibroblastic sarcomas, Gardner fibroma, scar tissue or keloids, superficial fibromatosis, nodular fasciitis, myofibroma, collagenous fibroma, gastrointestinal stromal tumor, solitary fibrous tumor, phyllodes tumor, and other conditions ...
Infantile digital fibromatosis; Infantile digital myofibroblastoma; Infantile hemangioma; Infantile hemangiopericytoma; Infantile kaposiform hemangioendothelioma; Infantile myofibromatosis; Infantile neuroblastoma; Infantile systemic hyalinosis; Intravascular papillary endothelial hyperplasia; Ischemic fasciitis