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Proline (symbol Pro or P) [4] ... [26] [better source needed] For proline's role in the stress response of plants, see § Biological activity. Specialties
In some plants, pipecolic acid act as a defense compound against microorganisms. [1] Because of its limited presence, pipecolic acid is considered a secondary metabolite. Structural formula for the amino acid proline, that in all living beings is a building block in proteins. Because of its universal presence, proline is considered a primary ...
Hydroxyproline and proline play key roles for collagen stability. [4] They permit the sharp twisting of the collagen helix. [5] In the canonical collagen Xaa-Yaa-Gly triad (where Xaa and Yaa are any amino acid), a proline occupying the Yaa position is hydroxylated to give a Xaa-Hyp-Gly sequence.
The confirmation of the enzyme plays a role in regulation depending on if GS is in the taut or relaxed form. The taut form of GS is fully active but, the removal of manganese converts the enzyme to the relaxed state. The specific conformational state occurs based on the binding of specific divalent cations and is also related to adenylation. [2]
In plants, their accumulation can increase survival during stresses such as drought. In extreme cases, such as in bdelloid rotifers , tardigrades , brine shrimp , and nematodes , these molecules can allow cells to survive being completely dried out and let them enter a state of suspended animation called cryptobiosis .
A reciprocal regulation of delta 1-pyrroline-5-carboxylate synthetase (P5CS) and proline dehydrogenase genes controls proline levels during and after osmotic stress in plants proportional to the level of proline. [10] This allows an optimum level of proline to be produced from reduced nitrogen to control osmotic stress.
Arginine and proline metabolism is one of the central pathways for the biosynthesis of the amino acids arginine and proline from glutamate. The pathways linking arginine, glutamate, and proline are bidirectional. Thus, the net utilization or production of these amino acids is highly dependent on cell type and developmental stage.
They are implicated in various aspects of plant growth and development, including root elongation, somatic embryogenesis, hormone responses, xylem differentiation, pollen tube growth and guidance, programmed cell death, cell expansion, salt tolerance, host-pathogen interactions, and cellular signaling.