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Tertiary dentin (including reparative dentin or sclerotic dentin) is a form of dentin, one of the main component materials of teeth. It forms as a reaction to stimulation, including caries , wear and fractures . [ 1 ]
Cross-section of a tooth. B is dentin. Dentin (/ ˈ d ɛ n t ɪ n / DEN-tin) (American English) or dentine (/ ˈ d ɛ n ˌ t iː n / DEN-teen or / ˌ d ɛ n ˈ t iː n / DEN-TEEN) (British English) (Latin: substantia eburnea) is a calcified tissue of the body and, along with enamel, cementum, and pulp, is one of the four major components of teeth.
Tertiary dentin can be divided into reactionary or reparative dentin. Reactionary dentin is formed by odontoblasts when the injury does not damage the odontoblast layer. Reparative dentin is formed by replacement odontoblasts when the injury is so severe that it damages a part of the primary odontoblast layer.
In the case of reparative dentin, other cells are needed to assume the role of the destroyed odontoblasts. Growth factors, especially TGF-β, [85] are thought to initiate the production of reparative dentin by fibroblasts and mesenchymal cells of the pulp. [86] Reparative dentin is produced at an average of 1.5 μm/day, but can be increased to ...
Dentin formation, known as dentinogenesis, is the first identifiable feature in the crown stage of tooth development. The formation of dentin must always occur before the formation of enamel. The different stages of dentin formation result in different types of dentin: mantle dentin, primary dentin, secondary dentin, and tertiary dentin. [31]
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In the case of an infection breaching the dentin to or very near the pulp, or in the instance of odontoblast death due to other attack (e.g. chemical or physical), undifferentiated mesenchymal cells can differentiate into odontoblast-like cells which then secrete another type, reparative dentin, underneath the site of attack.
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