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The adverse side effects of amphetamine are many and varied, and the amount of amphetamine used is the primary factor in determining the likelihood and severity of adverse effects. [ 29 ] [ 41 ] Amphetamine products such as Adderall , Dexedrine, and their generic equivalents are currently approved by the U.S. FDA for long-term therapeutic use.
Common effects may include increased alertness, awareness, wakefulness, endurance, productivity, and motivation, arousal, locomotion, heart rate, and blood pressure, and a diminished desire for food and sleep. Use of stimulants may cause the body to significantly reduce its production of endogenous compounds that fulfill similar functions.
During World War II, amphetamine and methamphetamine were used extensively by Allied and Axis forces for their stimulant and performance-enhancing effects. [ 4 ] [ 9 ] [ 10 ] As the addictive properties of the drugs became known, governments began to place strict controls on these drugs. [ 4 ]
[1] [3] For comparison, mescaline is typically used at doses of 200 to 500 mg and is said to have a duration of 10 to 12 hours or longer. [4] TMA's positional isomer 2,4,5-trimethoxyamphetamine (2,4,5-TMA or TMA-2) is much more potent than TMA, with a dosage of 20 to 40 mg and a duration of 8 to 12 hours.
The prescription medicine Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally. However, using non-prescribed drugs, using non-prescribed dose regimen, can cause polysubstance dependence , or combined drug intoxication which may lead to ...
Benzodiazepine use disorder (BUD), also called misuse or abuse, [1] is the use of benzodiazepines without a prescription and/or for recreational purposes, which poses risks of dependence, withdrawal and other long-term effects. [2] [3] Benzodiazepines are one of the more common
Amphetamine type stimulants can be used in the treatment of narcolepsy, a rare neurological disorder where the brain is unable to regulate the sleep-wake mechanism. [17] Amphetamines causes an increase in dopamine release, which is the proposed mechanism for its wake-promoting effect. [ 18 ]
MDA is bought, sold, and used as a recreational drug due to its enhancement of mood and empathy. [8] A recreational dose of MDA is sometimes cited as being between 100 and 160 mg. [9] It produces MDMA-like effects, including entactogen and psychedelic effects. [2] [9] [10]