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Spironolactone can also have numerous other interactions, most commonly with other cardiac and blood pressure medications, for instance digoxin. [8] Licorice, which has indirect mineralocorticoid activity by inhibiting mineralocorticoid metabolism, has been found to inhibit the antimineralocorticoid effects of spironolactone.
[21] [134] [20] Examples of such interactions include oral digoxin and estradiol. [136] [79] There is evidence that spironolactone may block voltage-dependent Ca 2+ channels [139] [140] and voltage-gated potassium (K +) channels. [141] Spironolactone has been identified as an inhibitor of NRG1‐ERBB4 signaling. [142]
However, spironolactone is metabolized to three active metabolites, which give it prolonged activity (13.8 – 16. 5 hours). Spironolactone has a long half-life and is excreted 47-51% through kidneys. Patients with chronic kidney disease therefore require close monitoring when taking the drug. Spironolactone is also eliminated through feces (35-41%
They can be used in combination with other anti-hypertensives or drugs that cause hypokalemia to help maintain a normal range for potassium. For example, they are often used as an adjunct to loop diuretics (usually furosemide) to treat fluid retention in congestive heart failure and ascites in cirrhosis. [11]
[1] [10] It is available both alone under the brand name Slynd and in combination with an estrogen under the brand name Yasmin among others. [10] [4] The medication is an analog of the drug spironolactone. [11] Drospirenone is taken by mouth. [1] [4] Common side effects include acne, headache, breast tenderness, weight increase, and menstrual ...
Eplerenone may have a lower incidence than spironolactone of sexual side effects such as feminization, gynecomastia, impotence, low sex drive and reduction of size of male genitalia. [18] This is because other antimineralocorticoids have structural elements of the progesterone molecule, causing progestogenic and antiandrogenic outcomes. [ 4 ]
Aldosterone antagonists: spironolactone, which is a competitive antagonist of aldosterone. Aldosterone normally adds sodium channels in the principal cells of the collecting duct and late distal tubule of the nephron. Spironolactone prevents aldosterone from entering the principal cells, preventing sodium reabsorption.
In other projects Wikimedia Commons; Wikidata item; Appearance. ... Template:Side effects of spironolactone in women in clinical studies for acne; Spirolactone;