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Mupirocin is not a viable antibiotic against MuH strains. Other antibiotic agents, such as azelaic acid, nitrofurazone, silver sulfadiazine, and ramoplanin have been shown to be effective against MuH strains. [17] Most strains of Cutibacterium acnes, a causative agent in the skin disease acne vulgaris, are naturally resistant to mupirocin. [21]
A targeted – as opposed to universal – decolonization approach is sometimes recommended because of increasing levels of mupirocin resistance. [79] Currently, only universal decolonization with mupirocin has been demonstrated to be an effective control measure and therefore selective administration of mupirocin is contraindicated. [72]
Mupirocin 2% ointment can be effective at reducing the size of lesions. A secondary covering of clothing is preferred. [ 79 ] As shown in an animal study with diabetic mice, the topical application of a mixture of sugar (70%) and 3% povidone-iodine paste is an effective agent for the treatment of diabetic ulcers with MRSA infection.
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[citation needed] Mupirocin is a topical antibiotic commonly used for superficial skin infections and has been approved by the FDA nasal decolonization. [7] [8] Though these are the most commonly used products, there are a number of alternative antibiotics and antiseptics, like povidone-iodine, that are used in decolonization. [citation needed]
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By culturing P. fluorescens, mupirocin (an antibiotic) can be produced, which has been found to be useful in treating skin, ear, and eye disorders. [23] Mupirocin free acid and its salts and esters are agents currently used in creams, ointments, and sprays as a treatment of methicillin-resistant Staphylococcus aureus infection.