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  2. Telmisartan/amlodipine - Wikipedia

    en.wikipedia.org/wiki/Telmisartan/amlodipine

    Telmisartan works by blocking the effects of angiotensin II while amlodipine works by decreasing calcium ion entry into smooth muscle and heart muscle. [2] The combination was approved for medical use in the United States in 2009. [2] The combination is on the World Health Organization's List of Essential Medicines.

  3. Calcium channel blocker - Wikipedia

    en.wikipedia.org/wiki/Calcium_channel_blocker

    Although the mechanism is unclear, increased insulin may mobilize glucose from peripheral tissues to serve as an alternative fuel source for the heart (the heart mainly relies on oxidation of fatty acids). Theoretical treatment with lipid emulsion therapy has been considered in severe cases, but is not yet standard of care.

  4. Amlodipine - Wikipedia

    en.wikipedia.org/wiki/Amlodipine

    Amlodipine, sold under the brand name Norvasc among others, is a calcium channel blocker medication used to treat high blood pressure, coronary artery disease (CAD) [10] and variant angina (also called Prinzmetal angina or coronary artery vasospasm, among other names). [11] It is taken orally (swallowed by mouth). [10]

  5. Antihypertensive - Wikipedia

    en.wikipedia.org/wiki/Antihypertensive

    In the VALUE trial, the ARB valsartan produced a statistically significant 19% (p=0.02) relative increase in the prespecified secondary end point of myocardial infarction (fatal and non-fatal) compared with amlodipine. [25] The CHARM-alternative trial showed a significant +52% (p=0.025) increase in myocardial infarction with candesartan (versus ...

  6. Telmisartan - Wikipedia

    en.wikipedia.org/wiki/Telmisartan

    Telmisartan's activity at the peroxisome proliferator-activated receptor delta (PPAR-δ) receptor has prompted speculation around its potential as a sport doping agent as an alternative to GW 501516. [17] Telmisartan activates PPAR-δ receptors in several tissues. In mice, this results in effects such as enhanced endurance.

  7. Levamlodipine - Wikipedia

    en.wikipedia.org/wiki/Levamlodipine

    Levamlodipine , also known as levoamlodipine or S-amlodipine is a pharmacologically active enantiomer of amlodipine. [1] Amlodipine belongs to the dihydropyridine group of calcium channel blocker used as an antihypertensive and antianginal agent. [2] It was approved by the U.S. FDA in December 2019 and is currently marketed under the brand name ...

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