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Human Endogenous Retrovirus-W (HERV-W) is a family of Human Endogenous Retroviruses (HERVs). HERVs are part of a superfamily of repetitive and transposable elements . Transposable elements are sequences of DNA that can move or "jump" around the genome, sometimes replicating and inserting themselves in different locations.
n/a Ensembl ENSG00000242950 n/a UniProt Q9UQF0 n/a RefSeq (mRNA) NM_014590 NM_001130925 n/a RefSeq (protein) NP_001124397 NP_055405 n/a Location (UCSC) Chr 7: 92.47 – 92.48 Mb n/a PubMed search n/a Wikidata View/Edit Human Syncytin-1 also known as enverin is a protein found in humans and other primates that is encoded by the ERVW-1 gene (endogenous retrovirus group W envelope member 1 ...
Dendrogram of various classes of endogenous retroviruses. Endogenous retroviruses (ERVs) are endogenous viral elements in the genome that closely resemble and can be derived from retroviruses. They are abundant in the genomes of jawed vertebrates, and they comprise up to 5–8% of the human genome (lower estimates of ~1%). [1] [2]
In addition, leukemia virus I (HTLV-1), found in human T cell, has been found in humans for many years. It is estimated that this retrovirus causes leukemia in the ages of 40 and 50. [30] It has a replicable structure that can induce cancer. In addition to the usual gene sequence of retroviruses, HTLV-1 contains a fourth region, PX.
Identical LTR sequences at either end of a retrotransposon. A long terminal repeat (LTR) is a pair of identical sequences of DNA, several hundred base pairs long, which occur in eukaryotic genomes on either end of a series of genes or pseudogenes that form a retrotransposon or an endogenous retrovirus or a retroviral provirus.
Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by the ERVFRD-1 gene. [5] This protein plays a key role in the implantation of human embryos in the womb. [6] This gene is conserved among all primates, with an estimated age of 45 million years. The receptor for this fusogenic env protein ...
The human genome includes many retroelements including the human endogenous retroviruses (HERVs), which compose about 7-8% of the human genome. [5] ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas.
The substitution rates for host COII gene and the SFV gene were found out to be (1.16 ± 0.35) × 10 −8 and (1.7 ± 0.45) × 10 −8 respectively. This is the slowest rate of substitution observed for RNA viruses and is closer to that of DNA viruses and endogenous retroviruses.