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Another application is to retrieve all TFs that regulate a given (set of) gene(s). In the context of systems-biological studies, the TF-target gene relations documented in TRANSFAC were used to construct and analyze transcription regulatory networks. [14] [15] By far the most frequent use of TRANSFAC is the computational prediction of potential ...
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells.
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
The discovery of the TCF/LEF genes as nuclear Wnt pathway components in the 90s [7] [8] was a pivotal breakthrough for the Wnt signalling research field, plugging an important knowledge gap and enabling subsequent understanding of transcriptional regulation of Wnt target genes, particularly in embryonic development and cancer.
Facilitated diffusion is the main mechanism behind the binding of Transcription Factors (TFs) to designated target sites on the DNA molecule. The in vitro model, which is a very well known method of facilitated diffusion, that takes place outside of a living cell , explains the 3-dimensional pattern of diffusion in the cytosol and the 1 ...
TF 20 was tasked with seizing airfields deep in Iraq and capturing HVTs along with providing long-range Special Reconnaissance; one of its primary pre-invasion targets was the planned seizure of Saddam International Airport in Baghdad, two full-scale rehearsals were carried out but the operation was never carried out and the airport was ...
An elderly Nevada man looking for love was allegedly drugged and pushed across the US border into Mexico in a wheelchair by a “sinister” scammer before being found dead in a Mexico City hotel ...
Transcription factor II H (TF II H) is an important protein complex, having roles in transcription of various protein-coding genes and DNA nucleotide excision repair (NER) pathways. TF II H first came to light in 1989 when general transcription factor-δ or basic transcription factor 2 was characterized as an indispensable transcription factor ...