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This choice would aid drug-discovery for the selected targets, as well as the development of both ligand-based and structure-based methods of computational ligand-design. This is the current focus of BindingDB, which is led by Michael Gilson , based at UC San Diego 's Skaggs School of Pharmacy and Pharmaceutical Sciences , and supported by a ...
A popular example of drug–food interaction is the effect of grapefruit on the metabolism of drugs. Interactions may occur by simultaneous targeting of receptors, directly or indirectly. For example, both Zolpidem and alcohol affect GABA A receptors, and their simultaneous consumption results in the overstimulation of the receptor, which can ...
Version 3.0 also included drug transporter data, drug pathway data, drug pricing, patent and manufacturing data as well as data on >5000 experimental drugs. Version 4.0 was released in 2014. [ 4 ] This version included 1558 FDA-approved small molecule drugs, 155 biotech drugs and 4200 unique drug targets.
Arrhythmia Dataset Data for a group of patients, of which some have cardiac arrhythmia. 276 features for each instance. 452 Text Classification 1998 [273] [274] H. Altay et al. Diabetes 130-US hospitals for years 1999–2008 Dataset 9 years of readmission data across 130 US hospitals for patients with diabetes.
1.6 million annotations. 238,906 video clips, 624,430 keyframes. Annotations, videos. Action prediction 2020 [126] [127] Li et al from Perception Team of Google AI. TV Human Interaction Dataset Videos from 20 different TV shows for prediction social actions: handshake, high five, hug, kiss and none. None. 6,766 video clips video clips Action ...
Type 2 diabetes is the most common type of diabetes. Treatments include agents that (1) increase the amount of insulin secreted by the pancreas, (2) increase the sensitivity of target organs to insulin, (3) decrease the rate at which glucose is absorbed from the gastrointestinal tract, and (4) increase the loss of glucose through urination.
Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):
The Human Protein Reference Database (HPRD) is a protein database accessible through the Internet. [1] It is closely associated with the premier Indian Non-Profit research organisation Institute of Bioinformatics (IOB), Bangalore, India. This database is a collaborative output of IOB and the Pandey Lab of Johns Hopkins University.