Search results
Results from the WOW.Com Content Network
Nizatidine is a histamine H 2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. [ 2 ] It was patented in 1980 and approved for medical use in 1988.
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
Ranitidine has 10% of the affinity that cimetidine has to CYP450, so it causes fewer side effects, but other H 2 blockers famotidine and nizatidine have no CYP450 significant interactions. [131] Ranitidine was introduced in 1981, and was the world's biggest-selling prescription drug by 1987. [132]
Main page; Contents; Current events; Random article; About Wikipedia; Contact us; Donate; Language links are at the top of the page.
Discover the best free online games at AOL.com - Play board, card, casino, puzzle and many more online games while chatting with others in real-time.
NEW JERSEY -- Another high-profile Democrat has thrown her hat into New Jersey's gubernatorial race. Congresswoman Mikie Sherrill launched her candidacy on YouTube early Monday morning She now ...
Famotidine, following the withdrawal of ranitidine Topics referred to by the same term This disambiguation page lists articles associated with the title Zantac .