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Altitude sickness, the mildest form being acute mountain sickness (AMS), is a harmful effect of high altitude, caused by rapid exposure to low amounts of oxygen at high elevation. [ 1 ] [ 2 ] [ 3 ] People's bodies can respond to high altitude in different ways.
Common side effects include numbness, ringing in the ears, loss of appetite, vomiting, and sleepiness. [2] It is not recommended in those with significant kidney problems, liver problems, or who are allergic to sulfonamides. [2] [4] Acetazolamide is in the diuretic and carbonic anhydrase inhibitor families of medication. [2]
High-altitude cerebral edema (HACE) is a medical condition in which the brain swells with fluid because of the physiological effects of traveling to a high altitude. It generally appears in patients who have acute mountain sickness and involves disorientation, lethargy, and nausea among other symptoms.
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Acetazolamide is an inhibitor of carbonic anhydrase.It is used for glaucoma, epilepsy (rarely), idiopathic intracranial hypertension, and altitude sickness. For the reduction of intraocular pressure (IOP), acetazolamide inactivates carbonic anhydrase and interferes with the sodium pump, which decreases aqueous humor formation and thus lowers IOP.
The effects of high altitude on humans are mostly the consequences of reduced partial pressure of oxygen in the atmosphere. The medical problems that are direct consequence of high altitude are caused by the low inspired partial pressure of oxygen, which is caused by the reduced atmospheric pressure, and the constant gas fraction of oxygen in ...
The primary recommendation for the prevention of HAPE is gradual ascent. [15] The suggested rate of ascent is the same that applies to the prevention of acute mountain sickness and high-altitude cerebral edema. The Wilderness Medical Society (WMS) recommends that, above 3,000 metres (9,800 ft), climbers
Employees of drugmaker WuXi AppTec, under U.S. scrutiny for its links to the Chinese military, co-invented altitude sickness treatments with People's Liberation Army (PLA) scientists, according to ...
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