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A bone tumor is an abnormal growth of tissue in bone, traditionally classified as noncancerous (benign) or cancerous (malignant). [ 1 ] [ 4 ] Cancerous bone tumors usually originate from a cancer in another part of the body such as from lung , breast , thyroid , kidney and prostate . [ 1 ]
They are formed from benign vasoformative neoplasms of endothelial cells that present as thin-walled vessels infiltrating the marrow, medullary cavity between bone trabeculae and are usually confined to the vertebral body. [11] VHs are commonly seen incidentally while obtaining imaging for other indications. [4]
Benign tumors of bone can be similar macroscopically and require a combination of a clinical history with cytogenetic, molecular, and radiologic tests for diagnosis. [23] Three common forms of benign bone tumors with are giant cell tumor of bone, osteochondroma, and enchondroma; other forms of benign bone tumors exist but may be less prevalent.
The more aggressive forms of disease require treatment with chemotherapy, radiotherapy, immunotherapy and—in some cases—a bone marrow transplant. The use of rituximab has been established for the treatment of B-cell–derived hematologic malignancies, including follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL).
Osteochondroma is the most common benign tumor of bone. [1] [2] The tumors take the form of cartilage-capped bony projections or outgrowth on the surface of bones . [3] [4] It is characterized as a type of overgrowth that can occur in any bone where cartilage forms bone. Tumors most commonly affect long bones around the knee and in the forearm.
Enchondroma is a type of benign bone tumor that originates from cartilage. The exact etiology of it is not known. An enchondroma most often affects the cartilage that lines the inside of the bones. The bones most often involved with this benign tumor are the miniature long bones of the hands and feet.
Osteoblastoma is an uncommon osteoid tissue-forming [1] primary neoplasm of the bone. It has clinical and histologic manifestations similar to those of osteoid osteoma; therefore, some consider the two tumors to be variants of the same disease, [2] with osteoblastoma representing a giant osteoid osteoma. However, an aggressive type of ...
A number of tumors have giant cells, but are not true benign giant-cell tumors. These include aneurysmal bone cyst, chondroblastoma, simple bone cyst, osteoid osteoma, osteoblastoma, osteosarcoma, giant-cell reparative granuloma, Giant-cell tumor of the tendon sheath and brown tumor of hyperparathyroidism. [citation needed]