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Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 5 × 10 8 /L (500/μL). [1] Hypereosinophilia is an elevation in an individual's circulating blood eosinophil count above 1.5 × 10 9 / L (i.e. 1,500/ μL ).
Eosinopenia is a condition where the number of eosinophils, a type of white blood cell, in circulating blood is lower than normal. [1] Eosinophils are a type of granulocyte and consequently from the same cellular lineage as neutrophils, basophils, and mast cells.
Depending on eosinophil target-organ infiltration, the clinical presentation of hypereosinophilic syndrome (HES) varies from patient to patient. [13] Individuals with myeloproliferative variant HES may be more likely to experience mucosal ulcerations involving the genitalia or airways, while patients with lymphocytic variant HES typically exhibit prominent skin symptoms such as urticarial ...
But, perhaps the most common cause for eosinophilia is an allergic condition such as asthma. In 1989, contaminated L-tryptophan supplements caused a deadly form of eosinophilia known as eosinophilia-myalgia syndrome , which was reminiscent of the toxic oil syndrome in Spain in 1981.
Peripheral blood eosinophilia and elevated serum IgE are usual but not universal. The damage to the gastrointestinal tract wall is caused by eosinophilic infiltration and degranulation. [15] As a part of host defense mechanism, eosinophils are normally present in gastrointestinal mucosa, though the finding in deeper tissue is almost always ...
Eosinophilic fasciitis (/ ˌ iː ə ˌ s ɪ n ə ˈ f ɪ l ɪ k ˌ f æ ʃ i ˈ aɪ t ɪ s, ˌ iː oʊ-,-ˌ f æ s i-/ [2] [3]), also known as Shulman's syndrome, [4] is an inflammatory disease that affects the fascia, other connective tissues, surrounding muscles, blood vessels and nerves.
Eosinophils play a central role in defending the body against infection by parasites. Many diseases, such as asthma and eczema, are caused when eosinophils overreact to environmental triggers and release an excess of chemicals, e.g., cytokines and histamine. The common characteristic among different causes of eosinophilic pneumonia is ...
Angiolymphoid hyperplasia with eosinophilia is characterized by papulonodular lesions on the head and neck that are violaceous or erythematous. [5] Lesions on the genital area, upper limbs, and trunk are uncommon. The lesions could be painful, pruriginous, or asymptomatic. Peripheral eosinophilia and lymphadenomegaly could be present. [6]