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These two cases suggest that there is an association between these drugs and taste disorders. This link is supported by the "de-challenge" and "re-challenge" that took place in both instances. [49] It appears that drug-induced dysgeusia can be alleviated by reducing the drug's dose or by substituting a second drug from the same class. [39]
Denatonium is commonly included in placebos used in clinical trials to mimic the bitter taste of certain medications. [1] Denatonium benzoate is an ingredient in certain nail polishes and varnishes designed to discourage nail biting, as the bitter denatonium serves as an aversive. [10]
Dysgeusia (usually a bitter or metallic taste) is present in about 60% of people with BMS, a factor which led to the concept of a defect in sensory peripheral neural mechanisms. [12] Changes in the oral environment, such as changes in the composition of saliva, may induce neuropathy or interruption of nerve transduction.
Taste sensitivity: Measured using strips impregnated with the four basic tastes — sweet, sour, salty, and bitter. Gene expression: By taking biopsies of participants’ tongues.
Quinine is also used as an ingredient in tonic water and other beverages to impart a bitter taste. [8] Common side effects include headache, ringing in the ears, vision issues, and sweating. [5] More severe side effects include deafness, low blood platelets, and an irregular heartbeat. [5] Use can make one more prone to sunburn. [5]
In the palliative care setting, anticholinergics and similar drugs that would normally reduce the production of saliva causing a dry mouth could be considered for symptom management: scopolamine, atropine, propantheline, hyoscine, amitriptyline, glycopyrrolate. [9]
Bitter taste and nausea are more common than most other adverse effects. [7] The oral suspension form produces a number of adverse effects including but not limited to: [13] Diarrhea; Abdominal pain; Rarely, tachycardia, bronchospasm, facial swelling, muscle aches; Both the oral suspension and the topical form can cause:
The most common side effect is a bitter taste (about 20% of people). Due to this, the manufacturer has produced another formulation of azelastine with sucralose . [ 22 ] The problem of bitter taste may also be reduced by correct application of the nasal spray (i.e. slightly tipping the head forward and not inhaling the medication too deeply ...