Search results
Results from the WOW.Com Content Network
Alzheimer's disease is a progressive neurodegenerative disorder associated with aging, which occurs both sporadically (the most common form of diagnosis) or due to familial passed mutations in genes associated with Alzheimer's pathology. [1] [2] Common symptoms associated with Alzheimer's disease include: memory loss, confusion, and mood ...
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase [1] whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
Incubate at 23 °C (73 °F) for 20 minutes; Centrifuge for 20 minutes at 16,000 G at 23 °C (73 °F) Invert filter and spin for 3 minutes at 2000 G; Bring the sample back to a neutral pH with 15-2uL 2.5M Tris pH9; Add ELISA buffer (1.5% BSA and 0.05% Tween 20 in phosphate buffered saline) Perform ELISA analysis.
The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy : a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain . [ 1 ]
In organic synthesis, PPTS is used as a weakly acidic catalyst, providing an organic soluble source of pyridinium (C 5 H 5 NH +) ions.For example, PPTS is used to deprotect silyl ethers or tetrahydropyranyl ethers when a substrate is unstable to stronger acid catalysts.
The negative charges create a repulsion that causes the polymer to swell. This swelling behavior is observed when the pH is greater than the pKa of the polymer. [2] Examples include polymethyl methacrylate polymers (pharmacologyonline 1 (2011)152-164) and cellulose acetate phthalate.
It is currently unclear as to whether or not primary age-related tauopathy (PART), a term in which includes some cases formerly referred to as neurofibrillary tangle-predominant dementia (NFTPD) or tangle-only dementia, is a variant of the traditional Alzheimer's disease, or a distinct entity.
The G s alpha subunit slowly catalyzes the hydrolysis of GTP to GDP, which in turn deactivates the G s protein, shutting off the cAMP pathway. The pathway may also be deactivated downstream by directly inhibiting adenylyl cyclase or dephosphorylating the proteins phosphorylated by PKA. Molecules that inhibit the cAMP pathway include: