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The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Schizophrenia is thought to have a heritable component in some people, but many people who appear to carry schizophrenia-associated genes may not develop the disease. [13] Research has shown that schizophrenia is a polygenic disorder and that genetic vulnerability to schizophrenia is highly multifactorial , caused by the interactions of several ...
Frontal cortex activity will be impaired, when combined with excess DA activity: the basis for the advancement of schizophrenia, but it is also the neurologic mechanism behind many other psychotic diseases as well. However, the genetic component is the primary source of the neurological abnormalities which leave one prone to psychological ...
Primary polydipsia, or excessive fluid intake, is relatively common in people with chronic schizophrenia. [ 232 ] [ 233 ] This may lead to hyponatremia which can be life-threatening. Antipsychotics can lead to a dry mouth , but there are several other factors that may contribute to the disorder; it may reduce life expectancy by 13 percent. [ 233 ]
Studies suggest that people with schizophrenia have a reduced hippocampus volume, which is believed to be caused by a reduction of adult neurogenesis. Correspondingly, this phenomenon might be the underlying cause of many of the symptoms of the disease.
Schizophrenia is not a particularly common mental health disorder in America, affecting just 1.2 percent of the population (around 3.2 million people), but its effects can be debilitating.
Instead of viewing schizophrenia as a by-product of brain evolution, one model presents schizophrenia to be one extreme of a sexually selected fitness indicator. [26] This model hypothesizes schizophrenia to be a side effect in sexual selection for certain traits. Sexual selection concerns the mating choices of humans and other animals.
Schizophrenia is a mental disorder that most commonly affects social and emotional functioning. Besides emotional and psychological influences, it is believed that genetics and early development play a role in the onset of schizophrenia. [8] The physical aspects of the disease are actual differences in the brain of the affected.
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