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[19] [20] Globally, Chagas disease is the leading cause of myocarditis, which results from infection with the protozoan Trypanosoma cruzi. [12] Bacteria can also result in myocarditis, although it is rare in patients with normal heart function and without a preexisting immunodeficiency. [18] [21] A list of the most relevant infectious organisms ...
Cardiotoxicity is the occurrence of heart dysfunction as electric or muscle damage, resulting in heart toxicity. [1] This can cause heart failure, arrhythmia, myocarditis, and cardiomyopathy in patients. [2] Some effects are reversible, while in others, permanent damage requiring further treatment may arise.
It is distinguished from non-eosinophilic myocarditis, which is heart inflammation caused by other types of white blood cells, i.e. lymphocytes and monocytes, as well as the respective descendants of these cells, NK cells and macrophages. This distinction is important because the eosinophil-based disorder is due to a particular set of ...
Two distinct drug classes in which cardiotoxicity can occur are in anti-cancer and antiarrhythmic drugs. Anti-cancer drug classes that cause cardiotoxicity include anthracyclines, monoclonal antibodies, and antimetabolites. This form generally manifests as a progressive form of heart failure, but can also manifest as an harmful arrhythmia. [2]
Cardiomyopathies are either confined to the heart or are part of a generalized systemic disorder, both often leading to cardiovascular death or progressive heart failure-related disability. Other diseases that cause heart muscle dysfunction are excluded, such as coronary artery disease, hypertension, or abnormalities of the heart valves. [17]
The study only documented myocarditis and pericarditis, rare inflammatory heart conditions, in the vaccinated group, but the incidences were very rare − 27 cases per million after the first dose ...
In very severe myocarditis cases, the virus actually replicates within the heart muscle cells, damaging them directly. These cases are often much more difficult to treat than cases related to ...
Coxsackie-induced cardiomyopathy is a potential result of virally induced myocarditis. This cardiomyopathy may present with symptoms such as chest pain, fatigue, heart failure, cardiogenic shock, arrhythmias or sudden death. [7] These symptoms are a by-product of sustained cardiac muscle damage.
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