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Amitriptyline, as the most commonly used of them, is recommended as a first-line agent for its therapy. [45] Amitriptyline may improve pain and urgency intensity associated with bladder pain syndrome and can be used in the management of this syndrome. [46] [47] Amitriptyline can be used in the treatment of nocturnal enuresis in children ...
Tricyclics have a narrow therapeutic index, i.e., the therapeutic dose is close to the toxic dose. [7] Factors that increase the risk of toxicity include advancing age, cardiac status, and concomitant use of other drugs. [8] However, serum drug levels are not useful for evaluating risk of arrhythmia or seizure in tricyclic overdose. [9]
In adolescents and people over age 60, therapy should be initiated at a dose of 5 mg three times a day and increased under the supervision of a physician as needed. [5] Patients over age 60 who are taking daily doses of 20 mg or more should be closely monitored for side effects such as rapid heart rate and urinary retention. [5]
Several cases of the misuse [65] of amitriptyline alone [66] [67] or together with methadone [65] [68] or in other drug dependent patients [69] [70] and of dosulepin with alcohol [71] or in methadone patients [72] have been reported.
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a first-generation antidepressant. [36] Nortriptyline may also have a sleep-improving effect due to antagonism of the H 1 and 5-HT 2A receptors. [37]
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Minitran 2-25: 2 mg Perphenazine and 25 mg Amitriptyline hydrochloride in each tablet. Minitran 4-10: 4 mg Perphenazine and 10 mg Amitriptyline hydrochloride in each tablet. Minitran 4-25: 4 mg Perphenazine and 25 mg Amitriptyline hydrochloride in each tablet. Minitran is also a pharmaceutical drug for the treatment of Angina, manufactured by 3M