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An evaluation of the western blot's ability to detect antibodies against F. tularensis revealed that its sensitivity is almost 100% and the specificity is 99.6%. [12] Some forms of Lyme disease testing employ western blotting. [13] A western blot can also be used as a confirmatory test for Hepatitis B infection and HSV-2 (Herpes Type 2) infection.
Physicians look to blood tests to support their diagnosis. Usually blood testing for Lyme is doneNow the diagnosis of Lyme disease is usually made by looking at antibodies against Borrelia proteins. via a test called a Western Blot. This test, called a Western Blot, is not always reliable.
Lyme disease, also known as Lyme borreliosis, is a tick-borne disease caused by species of Borrelia bacteria, transmitted by blood-feeding ticks in the genus Ixodes. [ 4 ] [ 9 ] [ 10 ] The most common sign of infection is an expanding red rash , known as erythema migrans (EM), which appears at the site of the tick bite about a week afterwards ...
There were more than 62,000 cases of Lyme disease reported to the US Centers for Disease Control and Prevention in 2022 – nearly a 70% jump from the annual average from 2017 to 2019, ...
The genomic variations have direct implications on the clinical symptoms of tick-borne Lyme disease. For example, the tick-borne Lyme disease caused by B. burgdorferi s.s. may manifest with arthritis-like symptoms. [9] In contrast, B. garinii’s tick-borne Lyme disease may cause an infection in the central nervous system. [9]
Borrelia burgdorferi is a bacterial species of the spirochete class in the genus Borrelia, and is one of the causative agents of Lyme disease in humans. [1] [2] Along with a few similar genospecies, some of which also cause Lyme disease, it makes up the species complex of Borrelia burgdorferi sensu lato.
Diagnosing Lyme borreliosis relies on clinical criteria, with a history of a tick bite and associated symptoms being crucial. Laboratory diagnosis follows a 'two-tiered diagnostic protocol,' involving detecting specific antibodies using methods such as immunoenzymatic assays and Western blot tests, preferably with recombinant antigens.
Eight are known to cause Lyme disease or Borreliosis. [6] The major Borrelia species causing Lyme disease are Borrelia burgdorferi, Borrelia afzelii, and Borrelia garinii. [23] All species that cause Lyme disease are referred to collectively as B. burgdorferi sensu lato, [10] while B. burgdorferi itself is specified as B. burgdorferi sensu stricto.