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A small proportion of humans show partial or apparently complete innate resistance to HIV, the virus that causes AIDS. [1] The main mechanism is a mutation of the gene encoding CCR5, which acts as a co-receptor for HIV. It is estimated that the proportion of people with some form of resistance to HIV is under 10%. [2]
Aaron James Traywick [1] (December 19, 1989 – April 29, 2018) was an American businessman and life extension activist in the transhumanism and biohacking communities. He sought to develop gene therapies [2] to make inexpensive treatments available for incurable conditions such as AIDS and the herpes simplex virus.
In 1996, Luigi Naldini and Didier Trono developed a new class of gene therapy vectors based on HIV capable of infecting non-dividing cells that have since then been widely used in clinical and research settings, pioneering lentivirals vector in gene therapy. [172] Jesse Gelsinger's death in 1999 impeded gene therapy research in the US.
As of April 2013, two primary approaches are being pursued in the search for a HIV cure: The first is gene therapy that aims to develop a HIV-resistant immune system for patients, and the second is being led by Danish scientists, who are conducting clinical trials to strip the HIV from human DNA and have it destroyed permanently by the immune ...
The Lazarus Effect is a 2010 documentary film about the positive impact of free antiretroviral drug therapy on HIV/AIDS patients in Africa. It was directed by Lance Bangs , and executive produced by Spike Jonze , after an organizer from AIDS awareness group Red suggested the project to them. [ 2 ]
Dallas Buyers Club a 2013 American biographical drama film written by Craig Borten and Melisa Wallack, and directed by Jean-Marc Vallée.The film tells the story of Ron Woodroof (Matthew McConaughey), a cowboy diagnosed with AIDS in the mid-1980s, a time when both the etiology and the treatment of HIV/AIDS are poorly understood and its sufferers subject to stigmatization.
Christine Joy Maggiore (July 25, 1956 – December 27, 2008) was an HIV-positive activist and promoter of HIV/AIDS denialism. [1] [2] She was the founder of Alive & Well AIDS Alternatives, an organization which disputes the link between HIV and AIDS and urges HIV-positive pregnant women to avoid anti-HIV medication. [3]
Scientists use the lentivirus' mechanisms of infection to achieve a desired outcome to gene therapy. Lentiviral vectors in gene therapy have been pioneered by Luigi Naldini. [3] [4] Structure of a virion of HIV, a type of lentivirus. A membrane with protruding glycoproteins surrounds a capsid containing enzymes and the viral RNA genome.
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