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Sprifermin. Sprifermin (INN) (developmental code name AS-902330), [1] is a recombinant human fibroblast growth factor 18 (rhFGF18) analog, [2] which is under development by TrialSpark for the treatment of osteoarthritis. [3] FGF18 and sprifermin act via the Fibroblast Growth Factor Receptor (FGFR) family, with preferential activity via FGFR3c.
The human body's own cartilage is still the best material for lining knee joints. This drives efforts to develop ways of using a person's own cells to grow, or re-grow cartilage tissue to replace missing or damaged cartilage. One cell-based replacement technique is called autologous chondrocyte implantation (ACI) or autologous chondrocyte ...
Artificial cartilage is a synthetic material made of hydrogels [1] or polymers that aims to mimic the functional properties of natural cartilage in the human body. Tissue engineering principles are used in order to create a non- degradable and biocompatible material that can replace cartilage. [2] While creating a useful synthetic cartilage ...
New research published in the New England Journal of Medicine had 407 people with obesity and knee osteoarthritis take semaglutide (the active component of Ozempic and Wegovy) or a placebo over 68 ...
Sodium hyaluronate is the sodium salt of hyaluronic acid. It is a glycosaminoglycan and long-chain polymer of disaccharide units of Na-glucuronate-N-acetylglucosamine. It can bind to specific receptors for which it has a high affinity. The polyanionic form, commonly referred to as hyaluronan, is a visco-elastic polymer found in the aqueous and ...
Editor’s note: Before beginning any new exercise program, consult your doctor.Stop immediately if you experience pain. Chances are you know someone who has had a total knee replacement. The ...
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