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Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed.
Fenfluramine is a substituted amphetamine and is also known as 3-trifluoromethyl- N -ethylamphetamine. [ 8 ] It is a racemic mixture of two enantiomers, dexfenfluramine and levofenfluramine. [ 8 ] Some analogues of fenfluramine include norfenfluramine, benfluorex, flucetorex, and fludorex.
Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. [18] In 1997, after 24 cases of heart valve disease in fen-phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. [19]
Ferroin is the chemical compound with the formula [Fe (o -phen) 3]SO 4, where o -phen is an abbreviation for 1,10- phenanthroline, a bidentate ligand. The term "ferroin" is used loosely and includes salts of other anions such as chloride. [1]
Fenfluramine was sold as a racemic mixture of two enantiomers, dexfenfluramine and levofenfluramine. [12] [13] In 1994, sales of the combination drug Fen-phen (fenfluramine and phentermine) increased dramatically, as this combination produced substantial and apparent synergistic effect in promoting weight loss. Subsequently, reports of severe ...
Dexfenfluramine, marketed as dexfenfluramine hydrochloride under the name Redux, is a serotonergic anorectic drug: it reduces appetite by increasing the amount of extracellular serotonin in the brain. [ 3 ] It is the d- enantiomer of fenfluramine and is structurally similar to amphetamine, but lacks any psychologically stimulating effects.
The study found that after the law went into effect prices saw a one-time increase of 3.7%, or about 15 cents for a $4 item. The study said that consumers absorbed about 62% of the cost increases ...
Anorectic. An anorectic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. [1] These substances work by affecting the central nervous system or certain neurotransmitters to create a feeling of fullness or reduce the desire to eat. The understanding of anorexiant effects is crucial in the development ...
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