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The New York Psychiatric Institute, associated with Columbia University, the Research Foundation of the City University of New York, and Mount Sinai Medical Center tested fenfluramine intravenously on more than 100 Black and Hispanic boys between the ages of 6 and 10, with delinquent older brothers, to test the theory that delinquent behavior could be predicted by serotonin levels.
Fenfluramine was an appetite suppressant which was used to treat obesity. [8] It was used both on its own and, in combination with phentermine, as part of the anti-obesity medication Fen-Phen. [8] In June 2020, fenfluramine was approved for medical use in the United States with an indication to treat Dravet syndrome. [7] [38]
[9] [10] Phentermine was withdrawn from the market in the United Kingdom in 2000, while the combination medication fen-phen, of which it was a part, was withdrawn from the market in 1997 due to side effects [11] of fenfluramine which caused increased levels of circulating serotonin which stimulated serotonin receptors on heart valves and thus ...
The FDA approved a new central nervous system stimulant called phentermine for weight loss in 1959. ... A short-lived weight loss medication emerged in the 1990s with the introduction of fen-phen ...
Fenfluramine was the main toxic component of the so-called ‘fen-phen’ combination. He led the renowned International Primary Pulmonary Hypertension Study (IPPHS), which was published in the prestigious New England Journal of Medicine in 1996, and which showed that fenfluramine had a causal role in primary pulmonary hypertension, a fatal ...
It is the d-enantiomer of fenfluramine and is structurally similar to amphetamine, but lacks any psychologically stimulating effects. Dexfenfluramine was, for some years in the mid-1990s, approved by the United States Food and Drug Administration for the purposes of weight loss .
Epidemics of fatal pulmonary hypertension and heart valve damage associated with pharmaceutical anorectic agents have led to the withdrawal of products from the market. This was the case with aminorex in the 1960s, and again in the 1990s with fenfluramine (see: Fen-phen). [7]
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