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  2. Sildenafil - Wikipedia

    en.wikipedia.org/wiki/Sildenafil

    Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [ 4 ] [ 8 ] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon . [ 9 ]

  3. 4 Common ED Pills: Weighing the Pros & Cons of Each - AOL

    www.aol.com/4-common-ed-pills-weighing-141800609...

    Vardenafil (Levitra) Vardenafil is the active ingredient in Levitra, and the FDA approved it in 2003. It’s similar to sildenafil but lasts longer — research suggests it provides better blood ...

  4. PDE5 inhibitor - Wikipedia

    en.wikipedia.org/wiki/PDE5_inhibitor

    Sildenafil was the first effective oral treatment available for ED. Because PDE5 is also present in the smooth muscle of the walls of the arterioles within the lungs, two PDE5 inhibitors, sildenafil and tadalafil, are FDA-approved for the treatment of pulmonary hypertension.

  5. cGMP-specific phosphodiesterase type 5 - Wikipedia

    en.wikipedia.org/wiki/CGMP-specific_phosphodi...

    The FDA approved Viagra on March 27, 1998. [20] Discovered by Pfizer , sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum in the penis.

  6. Your ED Pill Guide: Everything You Need to Know Before ... - AOL

    www.aol.com/ed-pill-guide-everything-know...

    The U.S. Food and Drug Administration (FDA) has approved several medications for the treatment of ED, including: Sildenafil (the active ingredient in Viagra or generic versions of Viagra ...

  7. Things You Probably Don't Know About Viagra (Like What ... - AOL

    www.aol.com/things-probably-dont-know-viagra...

    Generic sildenafil (and brand-name Viagra) is a medication for the treatment of ED, Raynaud’s phenomenon, and pulmonary arterial hypertension. To understand how Viagra works, we need to look at ...

  8. Discovery and development of phosphodiesterase 5 inhibitors

    en.wikipedia.org/wiki/Discovery_and_development...

    Sildenafil is a prototype of PDE5 inhibitors that Pfizer launched as Viagra. It was approved by the Food and Drug Administration (FDA) in 1998 as the first oral medicine for erectile dysfunction. Later, in the year 2005, it was approved for the treatment of pulmonary arterial hypertension. [2] Vardenafil and tadalafil were discovered in 1990.

  9. What Is the Safest ED Medication? - AOL

    www.aol.com/lifestyle/safest-ed-medication...

    Viagra (sildenafil), Cialis (tadalafil), Levitra (vardenafil), Stendra (avanafil) and Caverject (alprostadil) are all FDA-approved for the treatment of ED and safe for most men to use.

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