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  2. Opioid overdose - Wikipedia

    en.wikipedia.org/wiki/Opioid_overdose

    An opioid overdose results from over-activation of these receptors, which can cause permanent brain damage from cerebral hypoxia or neurotoxicity. [33] [7] Mu receptors have an analgesic effect on the brain, and are found in various parts of the nervous system including the cerebral cortex and thalamus. [16]

  3. Drug overdose - Wikipedia

    en.wikipedia.org/wiki/Drug_overdose

    The symptoms can often be divided into differing toxidromes. This can help one determine what class of drug or toxin is causing the difficulties. Symptoms of opioid overdoses include slow breathing, heart rate and pulse. [6] Opioid overdoses can also cause pinpoint pupils, and blue lips and nails due to low levels of oxygen in the blood.

  4. Wooden chest syndrome - Wikipedia

    en.wikipedia.org/wiki/Wooden_chest_syndrome

    Chest wall. Wooden chest syndrome is a rigidity of the chest following the administration of high doses of opioids during anesthesia [1]. [1]Wooden chest syndrome describes marked muscle rigidity — especially involving the thoracic and abdominal muscles — that is an occasional adverse effect associated with the intravenous administration of lipophilic synthetic opioids such as fentanyl [2].

  5. Opioid use disorder - Wikipedia

    en.wikipedia.org/wiki/Opioid_use_disorder

    Overdoses from opioids are highest among people between the ages of 40 and 50, [205] in contrast to heroin overdoses, which are highest among people between the ages of 20 and 30. [ 204 ] 21- to 35-year-olds represent 77% of people who enter treatment for opioid use disorder, [ 206 ] but the average age of first-time use of prescription ...

  6. Dying To Be Free - The Huffington Post

    projects.huffingtonpost.com/dying-to-be-free...

    Clinics that dispensed painkillers proliferated with only the loosest of safeguards, until a recent coordinated federal-state crackdown crushed many of the so-called “pill mills.” As the opioid pain meds became scarce, a cheaper opioid began to take over the market — heroin. Frieden said three quarters of heroin users started with pills.

  7. Benzodiazepine overdose - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine_overdose

    The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech. Severe symptoms include coma and respiratory depression. Supportive care is the mainstay of treatment of benzodiazepine overdose. There is an antidote, flumazenil, but its use is controversial. [2]

  8. Hypoxemia - Wikipedia

    en.wikipedia.org/wiki/Hypoxemia

    Tissue hypoxia refers to low levels of oxygen in the tissues of the body and the term hypoxia is a general term for low levels of oxygen. [2] Hypoxemia is usually caused by pulmonary disease whereas tissue oxygenation requires additionally adequate circulation of blood and perfusion of tissue to meet metabolic demands.

  9. Opioid-induced endocrinopathy - Wikipedia

    en.wikipedia.org/wiki/Opioid-induced_endocrinopathy

    Opioid-induced hyperprolactemia can lead to the painful growth of breast (gynecomastia), milk production (galactorhea) and hypogonadism. [ 1 ] Opioid-induced defect of hypothalamic–pituitary–somatotropic axis leads to growth hormone deficiency which in adults results in cognitive dysfunction, mainly affecting visuospatial memory and ...