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Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin ...
AOH1996 was created to target a post-translationally modified isoform of PCNA, termed caPCNA, which is preferentially found in cancer cells. PCNA is crucial in the body for DNA repair , but targeting it is difficult because of its role in healthy cells.
The following is a list of members of Bullet Club, a professional wrestling stable performing primarily in New Japan Pro-Wrestling (NJPW) and has also performed for several promotions such as All Elite Wrestling (AEW), Ring of Honor (ROH), Consejo Mundial de Lucha Libre (CMLL), Total Nonstop Action Wrestling (TNA, then Impact Wrestling), Revolution Pro Wrestling (RevPro) and various other ...
RFC is involved in the maintenance of telomeres, nuclear DNA replication, mismatch repair, and nucleotide excision repair. In the presence of ATP, RFC can load Proliferating cell nuclear antigen [PCNA] and DNA polymerase to form DNA-RFC-PCNA-DNA polymerase, which elongates in the presence of deoxynucleotides [dNTPs] via the action of human single-stranded DNA-binding protein [HSSB].
Although USAA has been a respected financial institution for decades, serving members of the military, veterans, and their families, it has landed in hot water with regulators and customers in ...
The M829 is an American armor-piercing fin-stabilized discarding sabot kinetic energy penetrator tank round.Modeling was done at the Ballistic Research Laboratory at Aberdeen Proving Ground, [1] which was incorporated into the Army Research Laboratory in 1992.
WASHINGTON (Reuters) -President-elect Donald Trump's pick to lead the U.S. Department of Defense, Pete Hegseth, on Wednesday said he is not backing down even as his nomination to lead the Pentagon ...
On Friday night in Dallas, Ohio State (12-2) meets Texas (13-2) in a collision of, arguably, college football’s two biggest brands with a trip to the national title game on the line. The meeting ...