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The human genome contains theta-defensin genes, but they have a premature stop codon, hampering their expression. An artificial human theta-defensin, [ 40 ] retrocyclin , was created by 'fixing' the pseudogene , and it was shown to be effective against HIV [ 41 ] and other viruses, including herpes simplex virus and influenza A .
Azurophils may contain myeloperoxidase, phospholipase A2, acid hydrolases, elastase, defensins, neutral serine proteases, bactericidal permeability-increasing protein, [1] lysozyme, cathepsin G, proteinase 3, and proteoglycans. [citation needed] Azurophil granules are also known as "primary granules". [2]
Lysozyme Identifiers EC no. 3.2.1.17 CAS no. 9001-63-2 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / QuickGO Search PMC articles PubMed articles NCBI proteins Protein family Glycoside hydrolase, family 22, lysozyme Lysozyme crystals stained with methylene ...
Double-stranded DNA phage lysins tend to lie within the 25 to 40 kDa range in terms of size. A notable exception is the streptococcal PlyC endolysin, which is 114 kDa. PlyC is not only the biggest and most potent lysin, but also structurally unique since it is composed of two different gene products, PlyCA and PlyCB, with a ratio of eight PlyCB subunits for each PlyCA in its active conformation.
Human neutrophil defensin-1, -3, and -4 are elevated in nasal aspirates from children with naturally occurring adenovirus infection. [10] In one small study, a significant increase in alpha-defensin levels was detected in T cell lysates of schizophrenia patients; in discordant twin pairs, unaffected twins also had an increase, although not as ...
Lysozyme is an antimicrobial enzyme that dissolves the cell walls of many bacteria, and phospholipase A2 is an enzyme specialized in the lysis of bacterial phospholipids. [10] This battery of secretory molecules gives Paneth cells a potent arsenal against a broad spectrum of agents, including bacteria, fungi and even some enveloped viruses .
100041688 Ensembl ENSG00000164816 ENSG00000285251 ENSMUSG00000061845 UniProt Q01523 E9QLQ1 RefSeq (mRNA) NM_021010 NM_001177481 RefSeq (protein) NP_066290 NP_001170952 Location (UCSC) Chr 8: 7.06 – 7.06 Mb Chr 8: 21.56 – 21.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Defensin, alpha 5 (DEFA5) also known as human alpha defensin 5 (HD5) is a protein that in humans is encoded ...
In crustaceans, transglutaminase from blood cells and mobile plasma proteins make up the clotting system, where the transglutaminase polymerizes 210 kDa subunits of a plasma-clotting protein. On the other hand, in the horseshoe crab clotting system, components of proteolytic cascades are stored as inactive forms in granules of hemocytes, which ...
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