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Myb genes are part of a large gene family of transcription factors found in animals and plants. In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper. [5] [6] Members of the extended SANT/Myb family also include the SANT domain and other similar all-helical homeobox-like domains.
The Myb domain (InterPro: IPR017930) acts by binding to double-stranded telomeric DNA. This region gets its name from a viral protein called Myb derived from the avian myeloblastosis virus. Specifically, the sequence that this Myb domain targets on the DNA is (GGTTAG/CCAATC)n.
4605 17865 Ensembl ENSG00000101057 ENSMUSG00000017861 UniProt P10244 P48972 RefSeq (mRNA) NM_002466 NM_001278610 NM_008652 RefSeq (protein) NP_001265539 NP_002457 NP_032678 Location (UCSC) Chr 20: 43.67 – 43.72 Mb Chr 2: 162.9 – 162.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene. Function The ...
17864 Ensembl ENSG00000185697 ENSMUSG00000025912 UniProt P10243 P51960 RefSeq (mRNA) NM_001080416 NM_001144755 NM_001294282 NM_001290397 NM_008651 RefSeq (protein) NP_001073885 NP_001138227 NP_001281211 NP_001277326 NP_032677 Location (UCSC) Chr 8: 66.56 – 66.61 Mb Chr 1: 9.74 – 9.77 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse MYB proto-oncogene like 1 is a protein that in ...
MYB may refer to: MYB (gene), a human gene; Myb, a plant transcription factor family; Marylebone station, London, by National Rail station code; Mbay language, by ISO ...
TERF 1 gene encodes a telomere specific protein which is a component of the telomere's shelterin nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. It is known to protect telomeres in mammals from ...
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions.
Some cell cycle dependent genes have been found where both CHRs and CDEs are in proximity to one another. Because p130-E2F4 can form stable associations with the MuvB complex, the proximity of CHRs to CDEs suggests that affinity of binding of the DREAM complex to target genes is cooperatively improved by association with both the binding sites ...