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In these tumors, the virus has integrated into the cancer cell genome and can no longer freely replicate. Recent studies from other laboratories have reproduced these findings: in one study 30 of 39 (77%) of Merkel cell tumors were MCV positive; [ 24 ] in another study, 45 of 53 (85%) Merkel cell tumors were positive.
Lymphoma with a histologic high grade generally respond better to treatment but have shorter survival times than dogs with low grade lymphoma. [6] Dogs with B-lymphocyte tumors have a longer survival time than T-lymphocyte tumors. [1] Mediastinal lymphoma has a poorer prognosis than other types, especially those with hypercalcemia. [12]
Murine polyomavirus (also known as mouse polyomavirus, Polyomavirus muris, or Mus musculus polyomavirus 1, and in older literature as SE polyoma or parotid tumor virus; abbreviated MPyV) is an unenveloped double-stranded DNA virus of the polyomavirus family. The first member of the family discovered, it was originally identified by accident in ...
Polyomaviruses are non-enveloped double-stranded DNA viruses with circular genomes of around 5000 base pairs. With such a small size, they are ranked among the smallest known double stranded DNA viruses. [12] The genome is packaged in a viral capsid of about 40-50 nanometers in diameter, which is icosahedral in shape (T=7 symmetry).
Tumor viruses come in a variety of forms: Viruses with a DNA genome, such as adenovirus, and viruses with an RNA genome, like the hepatitis C virus (HCV), can cause cancers, as can retroviruses having both DNA and RNA genomes (Human T-lymphotropic virus and hepatitis B virus, which normally replicates as a mixed double and single-stranded DNA ...
XMRV is a murine leukemia virus (MLV) that formed through the recombination of the genomes of two parent MLVs known as preXMRV-1 and preXMRV-2. [12] MLVs belong to the virus family Retroviridae and the genus gammaretrovirus and have a single-stranded RNA genome that replicates through a DNA intermediate.
SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans.Like other polyomaviruses, SV40 is a DNA virus that is found to cause tumors in humans and animals, but most often persists as a latent infection.
The SV40 LTag can induce S phase and activate the host cell's DNA damage response. [3] Coordinated actions of the OBD and helicase regions result in physical manipulation of the viral genome, melting the DNA double helix at the origin of replication and unwinding the circular DNA chromosome in a bidirectional fashion.
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