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Iowa (/ ˈ aɪ. ə w ə / ⓘ EYE-ə-wə) [6] [7] [8] is a state in the upper Midwestern region of the United States.It borders the Mississippi River to the east and the Missouri River and Big Sioux River to the west; Wisconsin to the northeast, Illinois to the east and southeast, Missouri to the south, Nebraska to the west, South Dakota to the northwest, and Minnesota to the north.