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Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are susceptible. [1] Symptoms include muscle rigidity , fever , and a fast heart rate . [ 1 ]
Serious side effects may include kidney problems, liver problems, low blood pressure, and malignant hyperthermia. [5] [4] It is unclear if it is safe in either pregnancy or breastfeeding. [5] It is only recommended in those who have a normal level of consciousness and stable blood pressure and heart rate. [4] It is classified as a volatile ...
Recreational drugs such as amphetamines [17] and cocaine, [18] PCP, dextromethorphan, LSD, and MDMA may cause hyperthermia. [2] Malignant hyperthermia is a rare reaction to common anesthetic agents (such as halothane) or the paralytic agent succinylcholine. Those who have this reaction, which is potentially fatal, have a genetic predisposition. [2]
Using anesthesia on your pet has changed over the years. The most up-to-date method is using an intravenous injection of induction drugs. How vets make anesthesia safer and how you need to keep ...
In cats, opioids alone are used to produce this effect. In dogs, a combination of an opioid and benzodiazepine can be used. [3] The second to last level is moderate sedation, which occurs for longer periods of time with stronger sedatives. Anesthetics that fit this category are other opioids, tranquilizers, benzodiazepines, and alpha-2 agonists.
Serious side effects can include malignant hyperthermia or high blood potassium. [4] It should not be used in patients with a history of malignant hyperthermia in either themselves or their family members. [3] It is unknown if its use during pregnancy is safe for the fetus, but use during a cesarean section appears to be safe.
Harrison experimentally induced malignant hyperthermia with halothane anesthesia in genetically susceptible pigs, and obtained an 87.5% survival rate, where seven of his eight experiments survived after intravenous administration of dantrolene.
An outgrowth of this committee, the Anesthesia Patient Safety Foundation, was created in 1985 as an independent, nonprofit corporation with the goal "that no patient shall be harmed by anesthesia". [73] The rare but major complication of general anaesthesia is malignant hyperthermia.