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Brain-derived neurotrophic factor (BDNF), or abrineurin, [5] is a protein [6] that, in humans, is encoded by the BDNF gene. [ 7 ] [ 8 ] BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4 /NT-5.
Thankfully, there are brain supplements for adults – specifically, vital vitamins that have been shown to boost brain function. These vitamins include B vitamins, vitamin D and omega-3 fatty acids.
A second mechanism is through the association of neurotrophic factors like nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF). These neurotrophic factors are proteins that are involved in the growth and survival of developing neurons and they are involved in the maintenance of ...
Nootropics (/ n oʊ. ə ˈ t r oʊ p ɪ k s / noh-ə-TROHP-iks or / n oʊ. ə ˈ t r ɒ p ɪ k s / noh-ə-TROP-iks), [1] colloquially brain supplements, smart drugs and cognitive enhancers, are natural, semisynthetic or synthetic compounds which purportedly improve cognitive functions, such as executive functions, attention or memory.
Neurotrophic factors are biomolecules – nearly all of which are peptides or small proteins – that support the growth, survival, and differentiation of both developing and mature neurons. [2] [3] [4] Examples of notable neurotrophic factors include: Insulin-like growth factor-1 (IGF-1) Glial cell line-derived neurotrophic factor (GDNF)
Among the TrkA agonists, the small molecule gambogic amide exerts a potent neurotrophic activity decreasing apoptosis in primary hippocampal neurons. [3] The non-peptidic TrkA agonist MT2 protects neurons from Aβ amyloid-mediated death in NGF-deficient neurons [4] and talaumidin and its derivatives show neuroprotective effects, promoting neurite outgrowth in PC12 cells. [5]
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