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General paresis, also known as general paralysis of the insane (GPI), paralytic dementia, or syphilitic paresis is a severe neuropsychiatric disorder, classified as an organic mental disorder, and is caused by late-stage syphilis and the chronic meningoencephalitis and cerebral atrophy that are associated with this late stage of the disease when left untreated.
Neurosyphilis is the infection of the central nervous system by Treponema pallidum, the bacterium that causes the sexually transmitted infection syphilis.In the era of modern antibiotics, the majority of neurosyphilis cases have been reported in HIV-infected patients.
The term "crazy" (from Middle English meaning cracked) and insane (from Latin insanus meaning unhealthy) came to mean mental disorder in this period. The term "lunacy", long used to refer to periodic disturbance or epilepsy, came to be synonymous with insanity. "Madness", long in use in root form since at least the early centuries AD, and ...
Ernst von Feuchtersleben is also widely credited as introducing the term in 1845, [152] as an alternative to insanity and mania. The term stems from Modern Latin psychosis , "a giving soul or life to, animating, quickening" and that from Ancient Greek ψυχή ( psyche ), "soul" and the suffix -ωσις (- osis ), in this case "abnormal condition".
Syphilis (/ ˈ s ɪ f ə l ɪ s /) is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. [1] The signs and symptoms depend on the stage it presents: primary, secondary, latent or tertiary.
Meningeal syphilis (as known as syphilitic aseptic meningitis or meningeal neurosyphilis) is a chronic form of syphilis infection that affects the central nervous system. Treponema pallidum , a spirochate bacterium, is the main cause of syphilis, which spreads drastically throughout the body and can infect all its systems if not treated ...
Walter Kaufmann speculates that he also contracted syphilis at a brothel along with his other infections at this time. [ 47 ] [ 48 ] On returning to Basel in 1870, Nietzsche observed the establishment of the German Empire and Otto von Bismarck 's subsequent policies as an outsider and with a degree of scepticism regarding their genuineness.
The definition and classification of mental disorders are key issues for researchers as well as service providers and those who may be diagnosed. For a mental state to be classified as a disorder, it generally needs to cause dysfunction. [15] Most international clinical documents use the term mental "disorder", while "illness" is also common.