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Brain cells make up the functional tissue of the brain. The rest of the brain tissue is the structural stroma that includes connective tissue such as the meninges , blood vessels , and ducts. The two main types of cells in the brain are neurons , also known as nerve cells, and glial cells , also known as neuroglia. [ 1 ]
(The term granule cell is used for several unrelated types of small neurons in various parts of the brain.) Cerebellar granule cells are also the most numerous neurons in the brain: in humans, estimates of their total number average around 50 billion, which means that they constitute about 3/4 of the brain's neurons. [1]
The cerebellar granule cells also play a role in orchestrating the tonic conductances which control sleep in conjunction with the ambient levels of GABA which are found in the brain. Dentate granule cells. Loss of dentate gyrus neurons from the hippocampus results in spatial memory deficits.
This is an accepted version of this page This is the accepted version, checked on 7 January 2025. There are template/file changes awaiting review. Central organ of the human nervous system "Brain tissue" redirects here. For brains in other animals, see Brain. Human brain The human brain, obtained after an autopsy Human brain and skull Details Precursor Neural tube System Central nervous system ...
The granule cells send their T-shaped axons—known as parallel fibers—up into the superficial molecular layer, where they form hundreds of thousands of synapses with Purkinje cell dendrites. The human cerebellum contains on the order of 60 to 80 billion granule cells, making this single cell type by far the most numerous neuron in the brain ...
In general, neuroglial cells are smaller than neurons. There are approximately 85 billion glia cells in the human brain, [8] about the same number as neurons. [8] Glial cells make up about half the total volume of the brain and spinal cord. [27] The glia to neuron-ratio varies from one part of the brain to another.
Glial cells play a major role in brain metabolism by controlling the chemical composition of the fluid that surrounds neurons, including levels of ions and nutrients. [85] Brain tissue consumes a large amount of energy in proportion to its volume, so large brains place severe metabolic demands on animals.
The Human Cell Atlas project, which started in 2016, had as one of its goals to "catalog all cell types (for example, immune cells or brain cells) and sub-types in the human body". [13] By 2018, the Human Cell Atlas description based the project on the assumption that "our characterization of the hundreds of types and subtypes of cells in the ...
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