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Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent ( dual antiplatelet therapy ). [ 10 ]
[18] [19] Unlike clopidogrel, prasugrel is effective in most individual with the exception in patients over the age of 75, weight under 60 kg, and patients with a history of stroke or TIA due to increased risk of bleeding, [20] [4] although several cases have been reported of decreased responsiveness to prasugrel. [21]
Low doses of aspirin (for example 75–150 mg) are as effective as high doses but have fewer side effects; the lowest effective dose remains unknown. [126] Thienopyridines (clopidogrel, ticlopidine) might be slightly more effective than aspirin and have a decreased risk of gastrointestinal bleeding but are more expensive. [127]
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
Consistently with its reversible mode of action, ticagrelor is known to act faster and shorter than clopidogrel. [35] This means it has to be taken twice instead of once a day which is a disadvantage in respect of compliance, but its effects are more quickly reversible which can be useful before surgery or if side effects occur. [24] [36]
The Comrey Personality Scales (also known as Comrey Personality Test or CPT) is a personality test developed by Andrew L. Comrey in 1970. The CPT measures eight main scales and two validity scales. [1] The test is currently distributed by Educational and Industrial Testing Service. The test consists of 180 items rated on a seven-point scale. [2]
A version of the test designed for adolescents ages 14 to 18, the MMPI-A, was released in 1992. The youth version was developed to improve measurement of personality, behavior difficulties, and psychopathology among adolescents. It addressed limitations of using the original MMPI among adolescent populations. [26]
The Psychopathic Personality Inventory (PPI-Revised) is a personality test for traits associated with psychopathy in adults. The PPI was developed by Scott Lilienfeld and Brian Andrews to assess these traits in non-criminal (e.g. university students) populations, though it is still used in clinical (e.g. incarcerated) populations as well.