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Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent ( dual antiplatelet therapy ). [ 10 ]
Antiplatelet drugs are widely used in primary and secondary prevention of thrombotic disease, especially myocardial infarction and ischemic stroke. [ 1 ] Antiplatelet therapy with one or more of these drugs decreases the ability of blood clots to form by interfering with the platelet activation process in primary hemostasis .
Consistently with its reversible mode of action, ticagrelor is known to act faster and shorter than clopidogrel. [35] This means it has to be taken twice instead of once a day which is a disadvantage in respect of compliance, but its effects are more quickly reversible which can be useful before surgery or if side effects occur. [24] [36]
Low doses of aspirin (for example 75–150 mg) are as effective as high doses but have fewer side effects; the lowest effective dose remains unknown. [126] Thienopyridines (clopidogrel, ticlopidine) might be slightly more effective than aspirin and have a decreased risk of gastrointestinal bleeding but are more expensive. [127]
[18] [19] Unlike clopidogrel, prasugrel is effective in most individual with the exception in patients over the age of 75, weight under 60 kg, and patients with a history of stroke or TIA due to increased risk of bleeding, [20] [4] although several cases have been reported of decreased responsiveness to prasugrel. [21]
Alan says that Ozempic can “potentially” cause personality changes. “Personality changes, as defined by alterations in behavior, mood, or cognition, are not commonly reported side effects of ...
Recent administration (within 7 days) of >650 mg/day of aspirin or other platelet inhibitors; Recent (within 3 months) ischemic stroke; Known or suspected intracranial AV malformation or aneurysm; Known bleeding diathesis (e.g., hemophilia) except for acute coagulopathy related to sepsis; Chronic severe hepatic disease
Cerebral infarction, also known as an ischemic stroke, is the pathologic process that results in an area of necrotic tissue in the brain (cerebral infarct). [1] In mid to high income countries, a stroke is the main reason for disability among people and the 2nd cause of death. [2]