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As per Falkow's original descriptions, the three postulates are: [1] "The phenotype or property under investigation should be associated with pathogenic members of a genus or pathogenic strains of a species. Specific inactivation of the gene(s) associated with the suspected virulence trait should lead to a measurable loss in pathogenicity or ...
Falkow is known as the father of the field of molecular microbial pathogenesis. [1] He formulated molecular Koch's postulates, which have guided the study of the microbial determinants of infectious diseases since the late 1980s. [2] Falkow spent over 50 years uncovering molecular mechanisms of how bacteria cause disease and how to disarm them. [1]
In 1988, microbiologist Stanley Falkow developed a set of three Molecular Koch's postulates for identifying the microbial genes encoding virulence factors. First, the phenotype of a disease symptom must be associated with a specific genotype only found in pathogenic strains. Second, that symptom should not be present when the associated gene is ...
Heinrich Hermann Robert Koch (/ k ɒ x / KOKH; [1] [2] German: [ˈʁoːbɛʁt ˈkɔx] ⓘ; 11 December 1843 – 27 May 1910) was a German physician and microbiologist.As the discoverer of the specific causative agents of deadly infectious diseases including tuberculosis, cholera and anthrax, he is regarded as one of the main founders of modern bacteriology.
Erwin Frink Smith (January 21, 1854 – April 6, 1927) was an American plant pathologist with the United States Department of Agriculture. He played a major role in demonstrating that bacteria could cause plant disease .
Hamilton Othanel Smith (born August 23, 1931 in New York) [1] is an American microbiologist and Nobel laureate. [ 2 ] [ 3 ] Smith graduated from University Laboratory High School of Urbana, Illinois .
Michael Smith CC OBC FRS [1] (April 26, 1932 – October 4, 2000) was a British-born Canadian biochemist and businessman. He shared the 1993 Nobel Prize in Chemistry [3] with Kary Mullis for his work in developing site-directed mutagenesis.
A crossword (or crossword puzzle) is a word game consisting of a grid of black and white squares, into which solvers enter words or phrases ("entries") crossing each other horizontally ("across") and vertically ("down") according to a set of clues. Each white square is typically filled with one letter, while the black squares are used to ...